09 Sep 2023

ajax loader responsive
About us | Advertise with us | Contact us

ajax loader
Posted: 21 April 2023 | Taylor Mixides (Drug Target Review) | No comments yet
Researchers have discovered that oligodendrocyte-lineage cells transfer cell material to neurons in a mouse brain. They have provided the first evidence of coordinated nuclear interaction between these cells and neurons.
In a study published in the Journal of Experimental Medicine researchers from University of California – Davis Health, US, have revealed how a particular type of brain cell, called oligodendrocyte-lineage cells, transfers cell material to neurons in the mouse brain. The researchers have provided the first evidence of coordinated nuclear interaction between these cells and neurons.
“This novel concept of material transfer to neurons opens new possibilities for understanding brain maturation and finding treatments for neurological conditions, such as Alzheimer’s disease, cerebral palsy, Parkinson’s, and Huntington’s disease,” said corresponding author Olga Chechneva. Assistant Project Scientist at the UC Davis Department of Biochemistry and Molecular Medicine.
Oligodendrocyte-lineage cells are a type of glial cell that can be found in the central nervous system. These cells are important for supporting the maturation of neural circuits from the time of birth. One of the main functions of oligodendrocyte-lineage cells is myelination, which involves creating a protective insulating layer called the myelin sheath around the nerve axons.
Satellite oligodendrocytes are a unique type of oligodendrocyte present in the grey matter of the central nervous system, near neuronal bodies. They play various roles, such as promoting the survival of neighbouring neurons, regulating the release of neurotransmitters, and adjusting synaptic activity.
“Research has mostly focused on studying the myelinating function of oligodendrocytes, while satellite oligodendrocytes and their interaction with neurons are not well understood,” Chechneva said.
The process of observing the interaction between glial cells and neurons began with an unplanned discovery. The scientists used unique fluorescent proteins to mark and follow the oligodendroglia in the brain and spinal cord of mice. To their surprise, they noticed that nuclear and ribosomal reporter proteins were not only found within these cells but also in the neurons of the mouse model.
Protein and molecule transfer is vital for neuronal survival and recovery post-injury. Material transfer occurs through tunnelling nanotubes, gap junctions, and extracellular vesicles. This study is the first to report material transfer to neurons by satellite oligodendrocytes in close contact with neurons, despite the interrupted plasma membrane.
“We are looking at the possibility of an additional new mechanism where the cell can directly transfer material to another cell, in particular a satellite oligodendrocyte to a neuron. We could clearly see that cell nuclei from both cells had come together, and the plasma membrane (the physical border between cells) was open,” Chechneva explained.
The study revealed that the transfer of materials between oligodendroglia and neurons starts to occur after birth, during a crucial time of brain development.
“The fact that this transfer process is established during postnatal development is very interesting. These are critical periods when the brain is maturing and brain circuits are formed,” Chechneva said.
“Our knowledge about this mechanism is extremely new, and it opens many questions for understanding how neurons work and its biological relevance in many neurological disorders. This is very exciting,” Chechneva added.
In addition to the above findings, the researchers observed that material transfer from oligodendroglia to neurons is heightened during chronic neuroinflammation. This discovery presents a potential avenue for developing more targeted therapies for neurodegenerative conditions that result from the accumulation of pathogenic proteins in neurons, including Alzheimer’s and Parkinson’s disease.
Related topics
Cell Therapy, Drug Delivery, Drug Discovery, Drug Discovery Processes, Drug Targets, In Vivo, Neurons, Neurosciences
Related conditions
Alzheimer’s, Parkinson’s
Related organisations
UC Davis Health, University of California (UC)
Related people
Olga Chechneva
By Taylor Mixides (Drug Target Review)
21 April 2023
No comments yet
Cell Therapy, Drug Delivery, Drug Discovery, Drug Discovery Processes, Drug Targets, In Vivo, Neurons, Neurosciences
Alzheimer’s, Parkinson’s
UC Davis Health, University of California (UC)
Olga Chechneva
All subscriptions include online membership, giving you access to the journal and exclusive content.
By Eurofins Discovery
By Bio-Techne
By Izzy Wood (Drug Target Review)
By Taylor Mixides (Drug Target Review)
By Drug Target Review
Your email address will not be published. Required fields are marked *







This site uses Akismet to reduce spam. Learn how your comment data is processed.
Write for us | Advertise with us
T: +44 (0)1959 563311
F: +44 (0)1959 563123

Drug Target Review is published by:
Russell Publishing Ltd.
Court Lodge
Hogtrough Hill
Brasted, Kent, TN16 1NU
United Kingdom
© Russell Publishing Limited, 2010-2023. All rights reserved. Terms & Conditions | Privacy Policy | Cookie Policy
Website development by e-Motive Media Limited.
This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorised as “Necessary” are stored on your browser as they are as essential for the working of basic functionalities of the website. For our other types of cookies “Advertising & Targeting”, “Analytics” and “Performance”, these help us analyse and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these different types of cookies. But opting out of some of these cookies may have an effect on your browsing experience. You can adjust the available sliders to ‘Enabled’ or ‘Disabled’, then click ‘Save and Accept’. View our Cookie Policy page.
Necessary cookies enable the core functionality of the website, including security, network management and accessibility. These cookies do not store any personal information. You may disable these by changing your browser settings, but this may affect how the website functions.

Cookie Type Duration Description
cookielawinfo-checkbox-advertising-targeting persistent 1 year The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category “Advertising & Targeting”.
cookielawinfo-checkbox-analytics persistent 1 year This cookie is set by GDPR Cookie Consent WordPress Plugin. The cookie is used to remember the user consent for the cookies under the category “Analytics”.
cookielawinfo-checkbox-necessary persistent 1 year This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category “Necessary”.
cookielawinfo-checkbox-performance persistent 1 year This cookie is set by GDPR Cookie Consent WordPress Plugin. The cookie is used to remember the user consent for the cookies under the category “Performance”.
PHPSESSID session 1 year This cookie is native to PHP applications. The cookie is used to store and identify a users’ unique session ID for the purpose of managing user session on the website. The cookie is a session cookies and is deleted when all the browser windows are closed.
viewed_cookie_policy persistent 1 year The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
zmember_logged session 1 year This session cookie is served by our membership/subscription system and controls whether you are able to see content which is only available to logged in users.

Advertising and targeting cookies help us provide our visitors with relevant ads and marketing campaigns.

Cookie Type Duration Description
advanced_ads_browser_width persistent 1 month This cookie is set by Advanced Ads and measures the browser width.
advanced_ads_page_impressions persistent 2 years This cookie is set by Advanced Ads and measures the number of previous page impressions.
advanced_ads_pro_server_info persistent 1 month This cookie is set by Advanced Ads and sets geo-location, user role and user capabilities. It is used by cache busting in Advanced Ads Pro when the appropriate visitor conditions are used.
advanced_ads_pro_visitor_referrer persistent 1 year This cookie is set by Advanced Ads and sets the referrer URL.
bscookie persistent 2 years This cookie is a browser ID cookie set by LinkedIn share Buttons and ad tags.
IDE persistent 2 years This cookie is set by Google DoubleClick and stores information about how the user uses the website and any other advertisement before visiting the website. This is used to present users with ads that are relevant to them according to the user profile.
li_sugr persistent 3 months This cookie is set by LinkedIn and is used for tracking.
UserMatchHistory persistent 1 month This cookie is set by Linkedin and is used to track visitors on multiple websites, in order to present relevant advertisement based on the visitor’s preferences.
VISITOR_INFO1_LIVE persistent 5 months This cookie is set by YouTube. Used to track the information of the embedded YouTube videos on a website.

Analytics cookies collect information about your use of the content, and in combination with previously collected information, are used to measure, understand, and report on your usage of this website.

Cookie Type Duration Description
bcookie persistent 2 years This cookie is set by LinkedIn. The purpose of the cookie is to enable LinkedIn functionalities on the page.
GPS persistent 30 minutes This cookie is set by YouTube and registers a unique ID for tracking users based on their geographical location
lang session 1 year This cookie is set by LinkedIn and is used to store the language preferences of a user to serve up content in that stored language the next time user visit the website.
lidc persistent 1 day This cookie is set by LinkedIn and used for routing.
lissc persistent 11 months This cookie is set by LinkedIn share Buttons and ad tags.
vuid persistent 2 years We embed videos from our official Vimeo channel. When you press play, Vimeo will drop third party cookies to enable the video to play and to see how long a viewer has watched the video. This cookie does not track individuals.
wow.anonymousId persistent 2 years This cookie is set by Spotler and tracks an anonymous visitor ID.
wow.schedule persistent 20 minutes This cookie is set by Spotler and enables it to track the Load Balance Session Queue.
wow.session persistent 20 minutes This cookie is set by Spotler to track the Internet Information Services (IIS) session state.
wow.utmvalues persistent 20 minutes This cookie is set by Spotler and stores the UTM values for the session. UTM values are specific text strings that are appended to URLs that allow Communigator to track the URLs and the UTM values when they get clicked on.
_ga persistent 2 years This cookie is set by Google Analytics and is used to calculate visitor, session, campaign data and keep track of site usage for the site’s analytics report. It stores information anonymously and assign a randomly generated number to identify unique visitors.
_gat persistent 1 minute This cookies is set by Google Universal Analytics to throttle the request rate to limit the collection of data on high traffic sites.
_gid persistent 1 day This cookie is set by Google Analytics and is used to store information of how visitors use a website and helps in creating an analytics report of how the website is doing. The data collected including the number visitors, the source where they have come from, and the pages visited in an anonymous form.

Performance cookies include cookies that deliver enhanced functionalities of the website, such as caching. These cookies do not store any personal information.

Cookie Type Duration Description
cf_ob_info persistent 1 minute This cookie is set by Cloudflare content delivery network and, in conjunction with the cookie ‘cf_use_ob’, is used to determine whether it should continue serving “Always Online” until the cookie expires.
cf_use_ob persistent 1 minute This cookie is set by Cloudflare content delivery network and is used to determine whether it should continue serving “Always Online” until the cookie expires.
free_subscription_only session 1 year This session cookie is served by our membership/subscription system and controls which types of content you are able to access.
ls_smartpush persistent 1 month This cookie is set by Litespeed Server and allows the server to store settings to help improve performance of the site.
one_signal_sdk_db persistent Until cleared This cookie is set by OneSignal push notifications and is used for storing user preferences in connection with their notification permission status.
YSC session 1 year This cookie is set by Youtube and is used to track the views of embedded videos.

source

Leave a Reply

Your email address will not be published. Required fields are marked *